Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area...
Publication Date
2017-04-20Author
Munde, Elly O
Raballah, Evans
Okeyo, Winnie A
Ong’echa, John M
Perkins, Douglas J
Ouma, Collins
Metadata
Show full item recordAbstract/ Overview
Background Improved understanding of the molecular mechanisms involved in pediatric
severe malarial anemia (SMA) pathogenesis is a crucial step in the design of novel
therapeutics. Identification of host genetic susceptibility factors in immune regulatory genes
offers an important tool for deciphering malaria pathogenesis. The IL-23/IL-17 immune
pathway is important for both immunity and erythropoiesis via its effects through IL-23
receptors (IL-23R). However, the impact of IL-23R variants on SMA has not been fully
elucidated. Methods Since variation within the coding region of IL-23R may influence the
pathogenesis of SMA, the association between IL-23R rs1884444 (G/T), rs7530511 (C/T),
and SMA (Hb< 6.0 g/dL) was examined in children (n= 369, aged 6–36 months) with P.
falciparum malaria in a holoendemic P. falciparum transmission area. Results Logistic …